Beef cows standing in a paddock

Clostridial Disease in Livestock: Use of Covexin®10 in High-value Animals

Susan Geddes

Written by Susan Geddes

Written by Susan Geddes
Vetlife Oxford veterinarian


Clostridial diseases remain one of the most significant preventable causes of sudden death in cattle. Conditions such as tetanus, pulpy kidney (enterotoxemia), and blackleg are widely recognised, but lesser-known diseases (including malignant oedema and sudden death syndrome) can be just as devastating. Unfortunately, treatment is rarely successful, due to the rapid onset of disease and the severe toxin-mediated tissue damage that occurs before clinical signs are observed.

In today’s market, where beef weaners are reaching record-high prices, and replacement dairy heifers represent a substantial investment, protecting high-value animals is more important than ever. The sudden and unexplained loss of a well-grown weaner or in-calf heifer is not only emotionally frustrating but also financially significant.

A common scenario reported by farmers is the unexpected death of one or more animals, often the best-performing individuals in the mob. These losses typically occur without prior signs of illness, and they are frequently described as ‘random’ or ‘overnight’ deaths. While this is often associated with youngstock, mixed-age cattle are also at risk, particularly during periods of dietary change or environmental challenge.

Clostridial bacteria are normal inhabitants of the gastrointestinal tract and are also widely present in soil. Under certain conditions, such as rapid feed changes, high carbohydrate intake, or increased soil ingestion, the bacteria can multiply rapidly and produce potent toxins. This risk is especially relevant for dairy cows and heifers transitioning onto winter crops such as kale and fodder beet, where soil contamination and sudden dietary shifts are common. In recent seasons, we have seen increased reports of sudden deaths in both youngstock and mixed-age animals while wintering on these crops in unvaccinated herds.

“The cost of vaccination is minimal compared with the financial impact of losing even a single high-value animal.”

Clostridial diseases are fully preventable with a comprehensive vaccination programme. Covexin® 10 provides protection against ten significant clostridial diseases affecting cattle, covering both common and lesser-recognised syndromes. When administered according to manufacturer guidelines, it offers reliable and cost-effective insurance against sudden death losses.

Most animals require an initial sensitiser vaccination followed by a booster four weeks later to establish solid immunity. Thereafter, an annual booster is required to maintain protection. In some herds or mobs, a realignment programme may be necessary to ensure all animals are on the same vaccination schedule, particularly when introducing purchased stock or managing mixed-age groups.

For beef weaners commanding premium prices, and dairy cows and heifers entering higher-risk feeding periods, vaccination should be considered an essential component of the preventative health plan.

The cost of vaccination is minimal compared with the financial impact of losing even a single high-value animal.

In an environment where margins matter and animal value continues to rise, proactive clostridial vaccination with Covexin® 10 is a simple, practical step to safeguard performance, welfare, and profitability.

Covexin® 10 in registered pursuant to ACVM number A009028.